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Androgen Deprivation Therapy

An Essential Guide for Prostate Cancer Patients and Their Loved Ones
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Androgen Deprivation Therapy is the only guide written exclusively about the side effects of hormone therapy. The authors have collaborated with the European Association of Urology to produce this specially revised new edition to serve men affected by ADT across the globe. This comprehensive workbook for prostate cancer patients and their loved ones is filled with practical advice from experts in the field. The book covers a wealth of strategies to help men cope with ADT and maintain a good quality of life while on this treatment. It is not only an informational manual, but a guide for both patients and partners about ways to make changes in their lives that can keep them healthy and positive when the patient is on ADT.New to this Edition: Updates on the primary drugs used to treat prostate cancer with tables for common brand names worldwide. Updates on the physical side effects of ADT, such as hot flashes, weight gain, muscle loss and fatigue-plus management strategies. Expanded information on exercise and nutrition for men diagnosed with prostate cancer. Expanded information on the psychological and relational impact of ADT on both patients and their partners, with strategies to maintain intimacy despite reduced libido and difficulties with erections. Expanded discussion on dealing with emotional side effects, such as mood swings and depression. Exercises, activities, worksheets, and other tools to promote discussion and inspire behavioral changes that can reduce the burden of ADT. Officially endorsed by the European Association of Urology and the Canadian Urological Association.
Richard J. Wassersug, PhD, is a research scientist who earned his doctoral degree in evolutionary biology from the University of Chicago in Illinois. He then spent most of his career studying the biology of amphibians and teaching anatomy in the medical school at Dalhousie University in Halifax, Nova Scotia. At the age of 52 years, he was diagnosed with prostate cancer and has received multiple treatments for the disease. After beginning androgen deprivation therapy, he redirected his research to study the psychology of androgen deprivation in various populations. Wassersug now holds the title of Honorary Professor at the University of British Columbia, Vancouver, Canada. Lauren M. Walker, PhD, R Psych, is an Adjunct Associate Professor in the Department of Oncology's Division of Psychosocial Oncology and the Department of Psychology at the University of Calgary in Alberta. She is a registered clinical psychologist in the province of Alberta and operates a private clinical psychology practice for individuals with sexual concerns (see www.drlaurenwalker.com). She completed a clinical fellowship in 2015 specializing in oncology and sexuality, where she focused on developing programs to help cancer patients adapt to sexual changes after cancer treatment. She received her doctorate in clinical psychology in 2013 from the University of Calgary. There she completed her dissertation, which evaluated a patient education initiative for prostate cancer patients (and their partners) starting androgen deprivation therapy. Walker established the University of Calgary's Oncology Sexual Health Lab and maintains an active research program. She also maintains an Instagram account aimed to decrease stigma and to disseminate scientific and clinical knowledge about sexuality (www.instagram. com/drlaurenwalker). John W. Robinson, PhD, R Psych, was a clinical psychologist and member of the Genitourinary and Gynaecological Cancer Programs at the Tom Baker Cancer Centre in Calgary, Alberta, from 1986 until he retired in 2019. Robinson's career focused on providing clinical services and creating and evaluating new ways to ease the psychological burden of cancer on not just patients but also their loved ones. He continues to hold an adjunct associate professorship in the Departments of Oncology (Division of Psychosocial Oncology) and Psychology at the University of Calgary, where he continues to be involved in research.
Foreword, Hendrik Van Poppel Foreword, Paul F. Schellhammer, MD, FACS Preface Introduction Before You Begin Will Reading This Book Make Me More or Less Anxious? I Have Never Read a Manual Before-Why Start Now? How to Read This Book What Are Your Values? Where to Go for Further Information Moving Forward: Questions for Discussion PART ONE: ANDROGEN DEPRIVATION THERAPY What Is Androgen Deprivation Therapy? How Does Androgen Deprivation Therapy Work? Abiraterone and Androgen Annihilation Androgen Receptor-Targeted Agents and Hormonal Intensification A More In-Depth Look at Luteinizing Hormone-Releasing Hormone Agonists Versus Antagonists Yet Other Forms of Androgen Deprivation Therapy The Original Androgen Deprivation Therapy The Future of Androgen Deprivation Therapy What Medications Are You Taking for Androgen Deprivation Therapy? How Long Will I Be on Androgen Deprivation Therapy? What Is the Prostate-Specific Antigen Test? How Is the Prostate-Specific Antigen Test Used for Men Who Have Been Treated for Prostate Cancer? How Is the Prostate-Specific Antigen Test Used When You Are on Androgen Deprivation Therapy? How Good Is the Prostate-Specific Antigen Test? How Long Will Androgen Deprivation Therapy Control My Cancer? Moving Forward: Questions for Discussion PART TWO: PHYSICAL SIDE EFFECTS Hot Flashes Medications A Device That May Help With Hot Flashes Counseling Activity: Abdominal Breathing/Paced Respiration Activity: Hot Flash Diary Weaker Bones Weight Gain and Muscle Loss Diabetes Metabolic Syndrome and Cardiovascular Risk Anemia and Fatigue Breast Growth and Discomfort Genital Shrinkage Loss of Body Hair Other Possible Side Effects Activity: Pros/Cons Table Activity: Action Plan Action Plan Example: Practice Abdominal Breathing to Help With Hot Flashes Activity: Goal Setting and Confidence Activity: Side Effects Self-Assessment Physical Side Effects: Essentials Moving Forward: Questions for Discussion PART THREE: EXERCISE Exercising Safely Caution Warm-Up Exercises Aerobic Exercises Resistance Training Keeping Your Bones Healthy Yoga and Tai Chi Cool Down Making the Decision to Exercise Habit and Reason Activity: Pros/Cons Table Setting Goals That Are SMART for You Example SMART Goals What Are Your SMART Goals? Activity: Matching Meaning and Change Using Self-Statements Meaning Self-Statements Preparing to Successfully Begin Exercising Your Action Plan When Do You Plan to Do It Where Do You Plan to Do It Who Might You Do It With Activity: Action Plan Action Plan Example: Start Walking Routinely Activity: Goal Setting and Confidence Maintaining Your Motivation Managing Lapses and Relapses Reward Yourself Support Activity: Identifying and Overcoming Barriers to Starting and Maintaining an Exercise Program Exercise: Essentials Moving Forward: Questions for Discussion PART FOUR: HEALTHY EATING Reading Food Labels Fats Protein Carbohydrates Determining Your Current Body Mass Index Estimating Your Nutritional Needs Omega-3 Fatty Acids Omega-6 Fatty Acids Soy Vitamin D How Do I Get Enough Vitamin D? Calcium Calcium in Your Diet Phytonutrients Polyphenols Punicalagin and Ellagic Acid Lycopene Activity: Pros/Cons Table Activity: Action Plan Action Plan Example: Eat Healthier Snacks Activity: Goal Setting and Confidence Healthy Eating: Essentials Moving Forward: Questions for Discussion PART FIVE: EFFECTS ON PSYCHOLOGICAL WELL-BEING Emotional Distress Emotional Expression Activity: Self-Assessment-Screening for Emotional Distress Depression Anxiety Activity: Progressive Muscle Relaxation Activity: Mindfulness Meditation Instructions Fatigue Grief Cognition Activity: Pros/Cons Table Activity: Action Plan Action Plan Example: Work on Stress Management Action Plan Activity: Goal Setting and Confidence Effects on Psychological Well-Being: Essentials Moving Forward: Questions for Discussion Emotional Changes Cognitive Changes PART SIX: EFFECTS ON INTIMATE RELATIONSHIPS AND SEXUALITY Androgen Deprivation Therapy Lowers Sexual Desire How the Loss of Sexual Desire Affects Couples Staying Close in Nonsexual Ways Making Time for Intimacy Dating Being Open and Honest Maintaining a Sexual Relationship Suggestions for Enjoying Sensual Pleasure With Low Sexual Desire Be Flexible About Who Initiates Intimacy Redefine Your Sexual Activities Take the Focus Off Orgasm Be Aware of Decreased Responsiveness to Sexual Touch Enhancing Awareness of Sensation With Mindfulness Stimulate Your Sexual Appetite Orgasms Without Ejaculation Sex: Beyond Intercourse Suggestions for Pleasing Your Female Partner Suggestions for Pleasing Your Male Partner Using Sexual Aids and Sex Toys Sexual Devices to Permit Insertive Sex Without Erections Treatments for Erectile Dysfunction General Comments on Using Erectile Assistive Aids Oral Medications Injections Intraurethral Suppositories Vacuum Pump Inflatable Penile Prosthesis Solo Masturbation The Use of Lubricants for Men Developing New Sexual Practices Activity: Beliefs Awareness Activity: Pros/Cons Table Activity: Action Plan Action Plan Example: Increasing Physical Affection With My Partner Action Plan Example: Getting Out More Activity: Goal Setting and Confidence Effects on Intimate Relationships and Sexuality: Essentials Moving Forward: Questions for Discussion Questions for Single Men Questions for Couples PART SEVEN: IMPACT ON COMMITTED RELATIONSHIPS Potential Changes in the Relationship Changes in the Way You Interact With Each Other Differences in Coping Style Increased Self-Doubt One Thing to Avoid Activity: Pros/Cons Table Activity: Action Plan Action Plan Example: Communicate More Effectively With My Partner Activity: Goal Setting and Confidence Impact on Committed Relationships: Essentials Moving Forward: Questions for Discussion PART EIGHT: UNIQUE CONSIDERATIONS FOR GAY RELATIONSHIPS Androgen Deprivation Therapy May Impact Committed Relationships for Gay Men Activity: Pros/Cons Table Activity: Action Plan Action Plan Example: Communicate More Effectively With My Partner Activity: Goal Setting and Confidence Unique Considerations for Gay Relationships: Essentials Moving Forward: Questions for Discussion PART NINE: CONCLUSION: STAYING HEALTHY Appendix Drug Chart Prostate-Specific Antigen (PSA) Chart Hot Flash Diary Pros/Cons Table Action Plan Goal Setting and Confidence Side Effects Self-Assessment Screening for Emotional Distress Mood Questionnaire, Symptoms of Distress Questionnaire Beliefs Awareness Exercise Glossary Resources Bibliography Acknowledgements Index Contributors About the Authors
Androgen deprivation therapy is the main treatment for locally advanced and metastatic prostate cancer. It is a very effective treatment, but it has major impact on many aspects of men's health. Thousands of articles have been dedicated to that subject. This book distills these down and provides a comprehensive understanding and path forward for the many challenges associated with androgen deprivation therapy."-David Crawford, M.D., Professor of Urology, University of California San Diego"As someone who has treated men with prostate cancer for over 25 years, I recognize the burden of care of the patients and their loved ones. This book provides excellent tips on how to deal with the disease. I have used prior versions for many years in my practice and wholly endorse this new version. It's a must read!" -Neil Fleshner, MD, Chair of Urology, University of Toronto Ontario, and Love Chair in Prostate Cancer Prevention, Princess Margaret Cancer Centre, Toronto, Ontario
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