A major benchmark in the understanding of psychiatric illness in children and adolescents, Developmental Psychopathology and Wellness reports on progress in identifying genetic and environmental influences on emotional-behavioral disorders. A team of 22 international authorities presents work that changes the way child psychiatry and clinical psychology are conceptualized, debunking misconceptions about depression, antisocial behavior, and other conditions to enhance our understanding of the causes of child psychopathology -- and improve the ways we treat these disorders. Coverage of basic principles describes the influence of genomic medicine, as explained by trailblazers in the field who demonstrate the importance of the developmental perspective. Chapters on gene-environment interaction review the important concepts of personality and temperament, cognition, and sex -- including findings from molecular genetic investigations on adolescent cognition, temperament, and brain function. Disorder-based examples show how emotional-behavioral illness and wellness attest to the interaction of genetic and environmental factors over time, providing new insight into the study of anxious depression, ADHD, autism, and antisocial personality disorders. And in considering how we can bridge the gap between research and clinical applications, Dr. Hudziak describes his family-based gene-environment approach as a means of better understanding etiopathology and treatment. Among the other significant contributions: Thomas Achenbach focuses on the importance of culture in understanding the genetic and environmental impact on children, with insights into measuring these sources of influence. Joan Kaufman reports on her seminal work on the genetic and environmental modifiers of risk and resilience in child abuse, relating maltreatment to other forms of environmental risk, genetic mediation, and reactivity. D. I. Boomsma describes the genetic architecture of childhood worry, presenting data from an extraordinary sample of 30,000 twin pairs. Frank Verhulst draws on a 14-year study to detail the advantages of the developmental perspective in understanding antisocial behavior. Stephen Faraone offers guidelines for moving beyond statistics to document the functional significance of DNA variants associated with psychopathology. As the contributors ably demonstrate, these new approaches to the care and treatment of at-risk children are applicable to daily practice, teaching, and research. Developmental Psychopathology and Wellness shows that these psychopathologies are not a matter of nature versus nurture or genes versus environment, but rather an intertwining web of them all.
ContributorsPrefacePart 1: BASIC PRINCIPLES OF DEVELOPMENTAL PSYCHOPATHOLOGYChapter 1. Developing Concepts in Developmental PsychopathologyChapter 2. Multicultural Perspectives on Developmental PsychopathologyChapter 3. Social Context and Developmental PsychopathologyPart 2: GENERAL CONCEPTS OF GENE--ENVIRONMENT INTERACTION ON CHILD DEVELOPMENTChapter 4. Temperament and Child Psychopathology: Beyond AssociationsChapter 5. Genetics of Personality and Cognition in AdolescentsChapter 6. Sex and Developmental PsychopathologyPart 3: DISORDER-BASED EXAMPLES OF THE STUDY OF GENE--ENVIRONMENT INTERACTIONChapter 7. Genetic and Environmental Modifiers of Risk and Resiliency in Maltreated ChildrenChapter 8. Genetic and Environmental Influences on Anxious/Depression: A Longitudinal Study in 3- to 12-Year-Old ChildrenChapter 9. Intersection of Autism and ADHD: Evidence for a Distinct Syndrome Influenced by Genes and by Gene--Environment InteractionsChapter 10. Genetic Epidemiology of Pervasive Developmental DisordersChapter 11. The Fourteen-Year Prediction of Antisocial BehaviorPart 4: THE FUTURE OF THE STUDY OF DEVELOPMENTAL PSYCHOPATHOLOGY IN GENETICS AND CLINICAL SETTINGSChapter 12. Statistical and Molecular Genetic Approaches to Developmental Psychopathology: The Pathway ForwardChapter 13. Genetic and Environmental Influences on Wellness, Resilience, and Psychopathology: A Family-Based Approach for Promotion, Prevention, and Intervention Index
