This new edition of The American Psychiatric Association Publishing Textbook of Mood Disorders is a systematic and painstaking reconceptualization of its predecessor. Under new editorial direction and with a revised roster of expert contributors, the second edition is an utterly current, clinically competent, and comprehensive text that will become an instant classic. The book is structured for learning and easy reference, moving deftly from symptomatology and epidemiology to pathogenesis and on to somatic interventions, cognitive-behavioral interventions, and psychotherapy. The latest science on genetics and epigenetics, brain imaging, and neurobiology are also examined in depth. Critically important to the clinician is the section on management of mood disorders, which provides treatment guidelines for major depressive disorder and bipolar disorder, as well as information on understanding, and preventing, suicide in children, adolescents, and adults. Finally, perspectives are offered on depression among women, children, and geriatric patients, as well as on depression across cultures. Practicing psychiatrists, residents, and students alike will benefit from the book's inclusive coverage. Topics new to this edition include the following: * Treatment-resistant depression-its definition and approaches to its treatment-is addressed in a dedicated chapter that covers diagnostic accuracy, pseudoresistance, comorbidity, pharmacological management, adjunctive strategies, psychotherapy, neuromodulation, and novel and experimental therapies.* Investigational agents, most notably ketamine and its relatives, constitute an exciting frontier in the treatment of mood disorders, and the clinical application, routes of delivery, dosing, risks, and clinical trials are explored in a dedicated chapter that is both rigorous and thorough.* There is compelling evidence that childhood maltreatment (defined as exposure to emotional, physical, and sexual abuse and neglect before the age of 18 years) is a prominent risk factor for the development of mood disorders as well as for a pernicious course and poor treatment response in mood disorders. These findings, as well as the underlying neurobiological and environmental interactions that may contribute to the development of mood disorders, are examined thoroughly and thoughtfully.* As our understanding of immune function in mood disorders has grown, psychoneuroimmunology has emerged as a focus of study likely to make major contributions to clinical practice in the coming decades. The book updates readers on this promising area of research. Over the last decade, depression has emerged as the leading cause of disability worldwide, with significant attendant morbidity and mortality. The American Psychiatric Association Publishing Textbook of Mood Disorders equips clinicians and trainees with the knowledge they need to alleviate suffering in their patients with mood disorders.
Charles B. Nemeroff, M.D., Ph.D., is the Matthew P. Nemeroff Professor and Chair of the Department of Psychiatry & Behavioral Sciences at the University of Texas, Austin, Dell Medical School. Natalie Rasgon, M.D., Ph.D., is a Professor in the Department of Psychiatry and Behavioral Sciences and Obstetrics and Gynecology at Stanford University School of Medicine and is also the Director of the Stanford Center for Neuroscience in Women's Health and the Associate Dean of Academic Affairs. Alan F. Schatzberg, M.D., is Kenneth T. Norris, Jr., Professor in the Department of Psychiatry and Behavioral Sciences at Stanford University School of Medicine in Stanford, California, where from 1991 to 2010 he was also the Chair of Psychiatry. He is currently Director of the Stanford Mood Disorders Center. Stephen M. Strakowski, M.D., is Vice Dean of Research and Associate Vice President, Regional Mental Health, at the Dell Medical School, University of Texas at Austin. He is also Professor of Psychiatry & Behavioral Sciences, Psychology, and Educational Psychology at the University of Texas, Austin.
ContributorsPrefacePart I: Symptomatology and EpidemiologyChapter 1. Historical Aspects of Mood DisordersChapter 2. Classifications of Mood DisordersChapter 3. The Epidemiology and Burdens of Mood DisordersChapter 4. Rating Scales and Structured Diagnostic Interviews for Mood DisordersPart II: Pathogenesis of Mood DisordersChapter 5. Neurochemistry of Mood DisordersChapter 6. Psychoneuroendocrinology of Mood DisordersChapter 7. Role of the Immune System in Mood DisordersChapter 8. Evolutionary Contributions to the Understanding of Mood and Mood DisordersPart III: Investigating Mood DisordersChapter 9. Anatomical PathologyChapter 10. Molecular and Cellular Neurobiology of Severe Mood DisordersChapter 11. Brain ImagingChapter 12. Review of Mood Disorder GeneticsChapter 13. Epigenetics of Mood DisordersPart IV: Somatic Interventions for Mood DisordersChapter 14. Tricyclics, Tetracyclics, and Monoamine Oxidase InhibitorsChapter 15. Selective Serotonin Reuptake Inhibitors, Serotonin-Norepinephrine Reuptake Inhibitors, and Other Related AntidepressantsChapter 16. Lithium and Mood StabilizersChapter 17. Use of Antipsychotic Medications in Mood DisordersChapter 18. Electroconvulsive Therapy in the Treatment of Mood DisordersChapter 19. Transcranial Magnetic Stimulation for Major Depressive DisorderChapter 20. Vagus Nerve Stimulation and Deep Brain StimulationChapter 21. Other Antidepressants: Trazadone, Mirtazapine, BupropionChapter 22. Ketamine and Other Investigational AgentsPart V: Psychotherapy of Mood DisordersChapter 23. Cognitive and Behavior Therapies for Major Depressive Disorder and Persistent Depressive DisorderChapter 24. Interpersonal Psychotherapy for Major Depressive Disorder and Persistent Depressive DisorderChapter 25. Psychoanalytic and Psychodynamic Psychotherapy for Depression and DysthymiaChapter 26. Psychotherapeutic Approaches to Bipolar DisorderChapter 27. Psychotherapy for Depression in Children and AdolescentsPart VI: Integrative Management of Mood DisordersChapter 28. Practice Guidelines for Major Depressive DisorderChapter 29. Guidelines for Treatment of Bipolar DisorderChapter 30. Understanding and Preventing SuicideChapter 31. Suicide in Children and AdolescentsChapter 32. Combination Strategies for the Pharmacological Treatment of Major Depressive DisorderChapter 33. Management of Treatment-Resistant DepressionPart VII: Subtypes of Mood DisordersChapter 34. Seasonal Affective Disorder and Light Therapy for Mood DisordersChapter 35. Atypical Depression, Dysthymia, and CyclothymiaChapter 36. Major Depressive Disorder With Psychotic FeaturesChapter 37. Pediatric Mood DisordersChapter 38. Geriatric Mood DisordersPart VIII: Additional Perspectives on Mood DisorderChapter 39. Depression in Primary CareChapter 40. Depression in Medical IllnessChapter 41. Mood Disorders and Substance UseChapter 42. Depression in WomenChapter 43. Depression Across Cultures: An Ecosocial ApproachChapter 44. Mood Disorders and SleepChapter 45. Childhood Maltreatment and Mood DisordersIndex
