Part I: Setting the Stage. Why Practice Harm Reduction Psychotherapy? What Is Harm Reduction Psychotherapy and Who Is It For? Part II: Harm Reduction Psychotherapy as an Integrated Treatment. Assessment as Treatment. Developing a Treatment Plan. The Fundamentals of Harm Reduction Psychotherapy. The Psychodynamic Matrix of Harm Reduction Psychotherapy. Motivational and Cognitive-Behavioral Contributions to Harm Reduction Psychotherapy. The Role of Biology in Harm Reduction Psychotherapy. Part III: Applications. Harm Reduction Psychotherapy in Community-Based Settings. Harm Reduction Psychotherapy in Groups. The Power of Connection: Working with Families and Friends of Drug Users. What Does It Take to Practice Harm Reduction Psychotherapy? Appendix A: Differential Diagnosis. Appendix B: Harm Reduction Supervision, Edith Springer. Appendix C: Additional Resources. Appendix D: Recommended Readings.