Preface. The problem: charge to the conference. The nosologic relationship between generalized anxiety disorder and major depression. Commentary on the nosologic relationship between generalized anxiety disorder and major depression. The biology of generalized anxiety disorder and major depressive disorder: commonalities and distinguishing features. What (no) differences in responses to three classes of psychotropics can teach us about distinctions between generalized anxiety disorders and major depressive disorder. Commentary on the biology of GAD and MAD and what (no) differences in responses to three classes of psychotropics can teach us about distinctions between GAD and MDD. Psychometric aspects of anxiety and depression. Commentary on psychometric aspects of anxiety and depression. The boundary between generalized anxiety disorder and the unipolar mood disorders: diagnostic and psychometric findings in clinical samples. Major depression and generalized anxiety disorders in the national comorbidity survey follow-up survey. The relationship of generalized anxiety disorder and major depression over time. Generalized anxiety disorder and major depression: common and reciprocal causes. Confirmatory factor analysis of common mental disorders across cultures. Commentary on confirmatory factor analysis of common mental disorders across cultures. Generalized anxiety disorder and depression: childhood risk factors in a birth cohort followed to age 32 years. Are there early adverse exposures that differentiate depression and anxiety risk? Episodes and disorders of general anxiety and depression. Are major depression and generalized anxiety disorder the same or different disorders? Discussion of the Dunedin and Medical Research Council birth cohort studies and the three generation high risk study. Toward a primary-care friendly DSM-V classification of emotional disorders: an integrative approach. Psychosocial origins of depressive and anxiety disorders. Commentaries on psychosocial origins of depressive and anxiety disorders, part 1. Commentaries on psychosocial origins of depressive and anxiety disorders, part 2. The relationship between generalized anxiety disorder and major depressive episode. Index.