In this video program, Dr. Carl W. Lejuez demonstrates and discusses his approach to therapy by working with a client seeking treatment for comorbid substance use and depression. The video highlights how the assessment provided with a functional analysis can lead seamlessly into the introduction of brief behavioral activation. This combined approach uses functional analysis to identify the environmental factors maintaining the substance use and depression, then transitions into a brief behavioral activation to help the client understand how refocusing one's life with valued activities can help create an environment conducive to a more meaningful, substance-free life.