Emotion-centered problem-solving therapy is a trans-diagnostic approach that teaches individuals, via an experiential learning framework, a series of skills geared to foster their flexibility and resilience when coping with major life stressors. Emotion-centered problem-solving therapy is the updated version of problem-solving therapy, which has more than 30 years of demonstrated efficacy regarding multiple clinical disorders, particularly depression. This newer version provides additional tools to help people better understand and regulate negative emotionality in order to more successfully problem-solve stressful life problems. In this video program, Dr. Arthur M. Nezu works with a client who is dealing with substantial life setbacks with the goal of enhancing his ability to both learn and apply the problem-solving skills. Dr. Christine Maguth Nezu discusses various teaching moments identified within this clinical demonstration that illustrate the four major toolkits that embody emotion-centered problem-solving therapy.