Nelson's Neonatal Antimicrobial Therapy

Joseph B. Cantey, MD, is an Associate Professor of Pediatrics in the Divisions of Pediatric Infectious Diseases and Neonatology/Perinatal Medicine at the University of Texas Health Science Center in San Antonio. He attended medical school at the Medical University of South Carolina before completing his pediatric residency at Johns Hopkins. He then completed dual fellowships in pediatric infectious diseases and neonatal/perinatal medicine at the University of Texas Southwestern in Dallas, Texas. His research interests include antimicrobial stewardship and responsible prescribing in the nursery setting; infection control and prevention in the nursery setting; and the pathogenesis, diagnosis, treatment, and longitudinal follow-up of congenital and perinatal infections, particularly herpes simplex virus, cytomegalovirus, and syphilis. Jason Sauberan, PharmD, is Assistant Clinical Professor at the University of California, San Diego, Skaggs School of Pharmacy and Pharmaceutical Sciences and a pediatric consultant pharmacist at the Helen Bernardy Center for Medically Fragile Children, Rady Children's Hospital San Diego. His research interests include anti-infection therapy, drugs in breast milk, parenteral nutrition, and medication safety. He serves on the Scientific Advisory Board of Mother to Baby California, and is an assistant clinical professor, UC San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences. John D. Nelson, MD is Professor Emeritus of Pediatrics at the University of Texas Southwestern Medical Center and Children's Medical Center, the same institution since he started his career back in 1957. At UT Southwestern he established the first formal Pediatric Infectious Disease fellowship program with Dr. Kenneth Haltalin and later Dr. George McCracken. He also went on to establish the National Pediatric Infectious Disease Seminar with Dr. McCracken and in 1982 they founded the Pediatric Infectious Disease Journal for which they continue as Chief Editors. In 1975 Dr. Nelson produced the first edition of the Pocket Book of Pediatric Antimicrobial Therapy which has gone through 20 biennial editions and is now edited by Dr. John Bradley.

Introduction 1. Choosing an Antibiotic for the Neonate 2. Antimicrobial Drug Therapy for Neonates A. Neonatal Pharmacokinetics B. Antimicrobial Pharmacodynamics C. Drug Dosage Tables D. Therapeutic Drug Monitoring E. Individual Drug Monographs ..... Acyclovir ..... Amphotericin B ..... Ampicillin ..... Cefazolin ..... Cefepime ..... Cefotaxime ..... Ceftazidime ..... Fluconazole ..... Gentamicin ..... Meropenem ..... Micafungin ..... Nafcillin/Oxacillin ..... Penicillin G ..... Piperacillin-Tazobactam ..... Vancomycin 3. Bacterial Infections in Neonates Conjunctivitis Gastrointestinal infections Osteomyelitis, suppurative arthritis Otitis media Parotitis, suppurative Pulmonary infections Sepsis and meningitis Skin and soft tissues Syphilis, congenital (<1 mo of age) Syphilis, congenital (>1 mo of age) Tetanus neonatorum Tuberculosis Urinary tract infection 4. Viral Infections in Neonates Cytomegalovirus Enterovirus Hepatitis B Hepatitis C Herpes simplex virus infection (HSV-1 and HSV-2) Human immunodeficiency virus Influenza A and B viruses Respiratory syncytial virus Varicella-zoster virus 5. Fungal Infections in Neonates Aspergillosis Candida spp Malassezia spp Mucormycosi Pneumocystis jiroveci pneumonia 6. Parasitic Infections in Neonates Amebiasis Babesiosis Chagas disease Cryptosporidium Giardiasis Malaria Scabies Toxoplasmosis, congenital 7. Antimicrobial Stewardship in the Nursery Index