* Preface* Acknowledgments* PART I: OVERVIEW*1. Introduction*2. Principles of Diagnosis*2.1 Specimen Type and Procurement*2.2 Ancillary Testing*2.3 Tumor Grading and Staging*3. Clinical and Radiographic Features*3.1 Clinical Information*3.2 Imaging of Soft Tissue and Bone Tumors Jamie T. Caracciolo* PART II: TUMORS OF SOFT TISSUE*4. Tumors With Adipose Differentiation*4.1 Lipoma With Variants*4.2 Spindle Cell/Pleomorphic Lipoma*4.3 Hibernoma*4.4 Lipoblastoma*4.5 Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma*4.6 Dedifferentiated Liposarcoma*5. Tumors With Myxoid Stroma*5.1 Ganglion Cyst*5.2 Myxoma*5.3 Aggressive Angiomyxoma*5.4 Myxoid Liposarcoma*5.5 Extraskeletal Myxoid Chondrosarcoma*5.6 Myxofibrosarcoma (High Grade) *6. Benign and Low-Grade Spindle Cell Tumors*6.1 Fibromas*6.2 Elastofibroma*6.3 Fibromatosis*6.4 Neurofibroma*6.5 Schwannoma*6.6 Perineurioma*6.7 Nodular Fasciitis*6.8 Additional Variants of Fasciitis*6.9 Angiomyofibroblastoma*6.10 Cellular Angiofibroma*6.11 Myofibroblastoma*6.12 Gastrointestinal Stromal Tumor*6.13 Leiomyoma*6.14 Myofibroma and Myofibromatosis*6.15 Solitary Fibrous Tumor*6.16 Low-Grade Fibromyxoid Sarcoma*7. Intermediate- to High-Grade Spindle Cell Tumors*7.1 Leiomyosarcoma*7.2 Dermatofibrosarcoma Protuberans*7.3 Infantile Fibrosarcoma*7.4 Adult Fibrosarcoma*7.5 Malignant Peripheral Nerve Sheath Tumor*7.6 Spindle Cell/Sclerosing Rhabdomyosarcoma*7.7 Synovial Sarcoma*8. Epithelioid Soft Tissue Tumors*8.1 Rhabdomyoma*8.2 Granular Cell Tumor*8.3 Glomus Tumor*8.4 Neoplasms With Perivascular Epithelioid Cell Differentiation (PEComa) *8.5 Myoepithelial Tumors of Soft Tissue*8.6 Clear Cell Sarcoma*8.7 Epithelioid Sarcoma*8.8 Alveolar Soft Part Sarcoma*9. Small Round Blue Cell Tumors*9.1 Embryonal Rhabdomyosarcoma*9.2 Alveolar Rhabdomyosarcoma*9.3 Desmoplastic Small Round Cell Tumor*9.4 Extrarenal Rhabdoid Tumor*9.5 Melanotic Neuroectodermal Tumor of Infancy*10. Giant Cell-Rich Tumors*10.1 Plexiform Fibrohistiocytic Tumor*10.2 Tenosynovial Giant Cell Tumors*10.3 Giant Cell Tumor of Soft Tissue*11. Soft Tissue Tumors With Inflammation*11.1 Angiomatoid Fibrous Histiocytoma*11.2 Myxoinflammatory Fibroblastic Sarcoma*11.3 Inflammatory Myofibroblastic Tumor*11.4 IgG4-Related Diseases*12. Vascular Tumors*12.1 Hemangiomas*12.2 Hemangioendothelioma*12.3 Kaposi Sarcoma*12.4 Angiosarcoma*13. Pleomorphic Soft Tissue Tumors*13.1 Pleomorphic Hyalinizing Angiectatic Tumor of Soft Parts*13.2 Pleomorphic Liposarcoma*13.3 Pleomorphic Myogenic Sarcomas (Rhabdomyosarcoma and Leiomyosarcoma) *13.4 Intimal Sarcoma*13.5 Undifferentiated/Pleomorphic Sarcoma*14. Soft Tissue Tumors With Osseous or Cartilaginous Matrix*14.1 Myositis Ossificans*14.2 Phosphaturic Mesenchymal Tumor*14.3 Tumoral Calcinosis*14.4 Synovial Chondromatosis*14.5 Ossifying Fibromyxoid Tumor of Soft Parts*14.6 Extraskeletal Osteosarcoma and Chondrosarcoma* PART III. TUMORS OF BONE*15. Osseous Lesions*15.1 Osteoma*15.2 Osteoid Osteoma*15.3 Osteoblastoma*15.4 Osteosarcoma*15.5 Major Histologic Variants of Osteosarcoma*15.6 Parosteal Osteosarcoma*15.7 Periosteal Osteosarcoma*16. Cartilaginous Lesions*16.1 Enchondroma*16.2 Osteochondroma and Bizarre Parosteal Osteochondromatous Proliferation (Nora's Lesion) *16.3 Chondroblastoma*16.4 Chondromyxoid Fibroma*16.5 Chordoma*16.6 Chondrosarcoma*16.7 Clear Cell Chondrosarcoma*17. Giant Cell-Rich Lesions*17.1 Langerhans Cell Histiocytosis (Eosinophilic Granuloma) *17.2 Giant Cell Lesion of Small Bones (Giant Cell Reparative Granuloma) *17.3 Giant Cell Tumor of Bone*18. Spindle Cell Tumors*18.1 Fibrous Dysplasia*18.2 Nonossifying Fibroma*18.3 Osteofibrous Dysplasia*18.4 Adamantinoma*18.5 Desmoplastic Fibroma of Bone*18.6 Undifferentiated High-Grade Sarcoma of Bone*19. Small Round Blue Cell Tumors*19.1 Ewing Sarcoma and Primitive Neuroectodermal Tumor*19.2 Lymphoma of Bone*19.3 Plasmacytoma*19.4 Mesenchymal Chondrosarcoma*20. Cystic Lesions*20.1 Aneurysmal Bone Cyst*20.2 Simple Bone Cyst* Selected Readings* Index